Early Development of Cancer
Oct. 19th, 17:20~18:20
Malignant tumors are caused by uncontrolled proliferation of transformed mutant cells that have lost the ability to maintain tissue integrity. The process of tumor development in which tissue organization is progressively disrupted appears to be contrast to embryogenesis or organogenesis. As cancer is alternatively dubbed as “neoplasm,” however, tumors arise as newly developing cells in a tissue. In fact, several issues in development biology such as growth and proliferation, angiogenesis and epithelial-mesenchymal transition are also can be seen in the process of tumor progression. In this session, we would like to discuss the early development of neoplasms which has been poorly understood.
Yoichiro Tamori, PhD, National Institute of Genetics
Epithelial tumors originate in tumor hotspots, a tissue-intrinsic microenvironment
Tohru Ishitani, PhD, Kyushu University
Apoptotic elimination of cells lacking harmony of Wnt/β-catenin signaling
Masato Enomoto, PhD, Kyoto University
Src drives cell-to-cell propagation of JNK signaling to control tumorigenesis and regeneration
Shunsuke Kon, PhD, Hokkaido University
Role of cell competition in multi-sequential carcinogenesis
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